! Без рубрики
*Letrozole: Description of the Drug*
Introduction
Letrozole is a medication primarily used in the treatment of hormone receptor-positive breast cancer. It belongs to a class of drugs known as aromatase inhibitors, which work by decreasing estrogen production in the body. This reduction in estrogen levels helps slow or reverse the growth of certain types of breast tumors that rely on this hormone.
What is Letrozole? – Description of the Drug
Chemical and Pharmacological Profile
Letrozole is a non-steroidal aromatase inhibitor with the chemical formula C17H11F3O. It functions by irreversibly inhibiting the enzyme aromatase, which is responsible for converting androgens into estrogens in postmenopausal women. This mechanism effectively lowers circulating estrogen levels, making it an effective therapy in hormone-sensitive breast cancers.
Indications
- Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women.
- Therapy for advanced or metastatic breast cancer.
- Off-label use in fertility treatments, particularly for ovulation induction in women with anovulatory infertility.
Administration and Dosage
Typically, letrozole is administered orally at a dose of 2.5 mg once daily. The duration of treatment varies based on the specific condition being treated and patient response. It is important to follow medical guidance for dosage adjustments and duration.
Mechanism of Action
The primary action of letrozole involves inhibition of the aromatase enzyme, leading to:
- Reduction of estrogen synthesis in peripheral tissues.
- Decrease in circulating estrogen levels.
- Suppression of estrogen-dependent tumor growth.
Potential Side Effects
Like all medications, letrozole can cause side effects. Common adverse reactions include:
- Hot flashes
- Joint pain or stiffness
- Fatigue
- Nausea
- Bone thinning or osteoporosis with long-term use
FAQs about Letrozole
Q1: How does letrozole differ from other hormonal therapies?
Letrozole specifically inhibits aromatase, reducing estrogen production postmenopause, unlike selective estrogen receptor modulators (SERMs) like tamoxifen which block estrogen receptors.
Q2: Can letrozole be used in premenopausal women?
Generally, letrozole is not recommended for premenopausal women unless https://letrozolebodybuilding.com/product/letrozol-stada-2-5mg-filmtabletten/ combined with ovarian suppression because their ovaries produce significant estrogen despite aromatase inhibition.
Q3: Are there any contraindications?
Yes, contraindications include hypersensitivity to letrozole and severe liver disease. Pregnant or breastfeeding women should avoid this drug due to potential risks to the fetus or infant.
Q4: How long should treatment with letrozole last?
The duration depends on the treatment plan, typically ranging from several months to years, based on clinical response and healthcare provider recommendations.
Conclusion
Letrozole plays a vital role in managing hormone receptor-positive breast cancer among postmenopausal women. Understanding its Description of the drug, mechanism, and potential side effects helps optimize its use for better therapeutic outcomes.
